Direct asymmetric aldol reaction of acetone with alpha-ketoesters catalyzed by primary-tertiary diamine organocatalysts

作者：Jiang Zhaoqin; Lu Yixin^*

来源：Tetrahedron Letters, 2010, 51(14): 1884-1886.

DOI：10.1016/j.tetlet.2010.02.044

Novel primary-tertiary diamine organocatalysts derived from L-serine were utilized to promote enantioselective aldol reaction of acetone with alpha-ketoesters. The desired products were obtained in high yields and with good to excellent enantioselectivities (up to 95% ee).

• 出版日期2010-4-7