A split-face, single-blinded, randomized controlled comparison of alexandrite 755-nm picosecond laser versus alexandrite 755-nm nanosecond laser in the treatment of acquired bilateral nevus of Ota-like macules

作者：Yu, Wenyou; Zhu, Jiafang; Yu, Wenxin; Lyu, Dongze; Lin, Xiaoxi; Zhang, Zhen^*

来源：Journal of the American Academy of Dermatology, 2018, 79(3): 479-486.

DOI：10.1016/j.jaad.2017.12.053

• acquired bilateral nevus of Ota-like macules
• photomechanical effect
• picosecond alexandrite laser
• postinflammatory hyperpigmentation
• Q-switched alexandrite laser

Background: Q-switched alexandrite lasers (QSALs) have been used for the treatment of acquired bilateral nevus of Ota-like macules (ABNOMs). Currently, picosecond alexandrite laser (PSAL) pulses have become available for pigmentary disorders. However, no studies have compared PSAL and QSAL in the treatment of ABNOM.
Objective: We sought to compare the efficacy and safety of PSAL and QSAL in the treatment of ABNOM.
Methods: Each patient (n = 30) received 3 treatments at 6-month intervals. Matching areas were delimitated on the face of each patient (left/right comparison); 1 side was treated with PSAL and the other side was treated with QSAL. The safety and efficacy of the 2 lasers were determined by visual assessment and self-report from patients 6 months after the final treatment.
Results: The P SAL-treated area achieved significantly better clearance (3.73 vs 2.4) with less severe pain (4.47 vs 5.16). The incidence rate of postinflammatory hyperpigmentation was 27.77% and 54.44% for the PSAL and QSAL treatments, respectively, and the duration of postinflammatory hyperpigmentation was 1.32 and 1.74 months, respectively (P < .001).
Limitations: The limitations of our study include the small sample size and the lack of objective evaluation.
Conclusion: Compared with QSAL, PSAL therapy afforded significantly better clinical outcomes and fewer side effects in the treatment of ABNOM.

• 出版日期2018-9
• 单位上海交通大学