Ameliorated effects of green tea extract on lead induced liver toxicity in rats

作者：Mehana E E; Meki Abdel Raheim M A; Fazili Khalid Majid^*

来源：Experimental and Toxicologic Pathology, 2012, 64(4): 291-295.

DOI：10.1016/j.etp.2010.09.001

• Rat liver
• Lead toxicity
• Green tea extract
• Enzyme antioxidants
• SOD
• GST

In the present study, the effect of green tea extract (GTE) on lead induced toxicity was studied in Sprague Dawley rats. Four groups of rats were used in the study. Lead and GTE was given orally to the rats with drinking water for 8 weeks. Lead concentration in the digested tissues of liver was detected using atomic absorption spectroscopy. The activities of glutathione-S-transferase (GST) and superoxide dismutase (SOD) were used as markers to evaluate the anti oxidant status of tissues. Lead exposure was found to attenuate the antioxidant potential of liver, which was however augmented when supplemented with green tea extract. Liver enzymes ALT. AST and ALP and serum protein determinations indicated the protective effects of green tea extract. Histopathological studies of liver revealed that supplementation of green tea extract resulted in mild degeneration and congestion of the blood vessels and an enhanced regenerative capacity.

• 出版日期2012-5