科研之友
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摘要
Copper has been used for centuries as a therapeutic agent in various cultures around the globe. With the emergence and spread of antibiotic resistance, the use of metallic copper alloys to control pathogenic microorganisms is attracting increasing attention. The antimicrobial effects of copper surfaces have been repeatedly demonstrated in both laboratory studies and clinical trials and copper surfaces have been attributed with great potential to limit the transmission and spread of pathogenic microbes. We investigated the antimicrobial effect of copper on three multidrug-resistant bacterial strains: methicillin-resistant Staphylococcus aureus sequence type 398, CTX-M-15 producing Escherichia coli and NDM-1 producing Klebsiella pneumoniae. Copper coupons were inoculated with bacterial cell suspensions and incubated at room temperature. At set time points, bacteria were resuspended and plated onto nutrient agar and colony-forming units were counted. Results show a more than fivefold log-reduction of viable bacteria for CTX-M-15 producing E. coil and NDM-1 producing K. pneumoniae after 60 min of incubation on metallic copper compared to stainless steel. The same reduction of viable bacteria could be demonstrated for methicillin-resistant S. aureus sequence type 398 after 120 min of incubation. Our data complement scientific evidence for copper's antimicrobial properties on multidrug-resistant bacteria and suggest that the use of copper surfaces constitutes an approach to support the control of these organisms.
- 出版日期2012
- 单位河北医科大学
