科研之友
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摘要
Since amphiphilic polymers carrying adhesive domains can be used for cell surface modification, they induce cell adhesion by acting as cell glues. For example, conjugation of single stranded DNA (ssDNA) or cell-penetrating peptide to poly(ethylene glycol)-conjugated phospholipid (PEG-lipid) made it possible to induce cell-cell attachment and cell-substrate attachment. These PEG-lipid derivatives are very convenient for this purpose because they are not taken up into cells and are localized on the cell surface, which means that the adhesive domains are displayed on the cell surface. In future our PEG-lipid derivatives will be useful for cell-based arrays for drug screening and high-throughput gene analyses, and pancreatic islet transplantation and regenerative medicine which require 3D tissue structures.
- 出版日期2018
