Absence of obesity paradox in Saudi patients admitted with acute coronary syndromes: insights from SPACE registry

作者：Mobeirek Abdulelah Fahad^*; Al Habib Khalid; Al Faleh Husam; Hersi Ahmed; Kashour Tarek; Ullah Anahar; Mimish Layth Ahmed; AlSaif Shukri; Taraben Amir; Alnemer Khalid; AlShamiri Mostafa

来源：ANNALS OF SAUDI MEDICINE, 2014, 34(1): 38-45.

DOI：10.5144/0256-4947.2014.38

BACKGROUND AND OBJECTIVES: To describe the distribution of body mass index (BMI) and its relationship with clinical features, management, and in-hospital outcomes of patients admitted with acute coronary syndromes (ACS). %26lt;br%26gt;DESIGN AND SETTINGS: The Saudi Project for Assessment of Coronary Events is a prospective registry. ACS patients admitted to 17 hospitals from December 2005-2007 were included in this study. %26lt;br%26gt;METHODS: BMI was available for 3469 patients (68.6%) admitted with ACS and categorized into 4 groups: normal weight, overweight, obese, and morbidly obese. %26lt;br%26gt;RESULTS: Of patients admitted with ACS, 72% were either overweight or obese. A high prevalence of diabetes (57%), hypertension (56.6%), dyslipidemia (42%), and smoking (32.4%) was reported. Increasing BMI was significantly associated with diabetes, hypertension, and hyperlipidemia. Overweight and obese patients were significantly younger than the normal-weight group (P=.006). However, normal-weight patients were more likely to be smokers and had 3-vessel coronary artery disease, worse left ventricular dysfunction, and ST elevation myocardial infarction. Glycoprotein IIb-IIIa antagonists were used significantly more in overweight, obese, and morbidly obese ACS patients than in normal-weight patients (P=.001). Coronary angiography and percutaneous intervention were reported more in overweight and obese patients than in normal-weight patients (P=.001). Inhospital outcomes were not significantly different among the BMI categories. %26lt;br%26gt;CONCLUSION: High BMI is prevalent among Saudi patients with ACS. BMI was not an independent factor for in-hospital outcomes. In contrast with previous reports, high BMI was not associated with improved outcomes, indicating the absence of obesity paradox observed in other studies.

• 出版日期2014-2