A proteomic investigation of Streptococcus agalactiae reveals that human serum induces the C protein beta antigen and arginine deiminase

作者：Yang Qian; Zhang Meng; Harrington Dean J; Black Gary W; Sutcliffe Iain C^*

来源：Microbes and Infection, 2011, 13(8-9): 757-760.

DOI：10.1016/j.micinf.2011.03.001

• C protein Beta antigen
• Colonisation
• Group B Streptococcus
• Proteomics
• Sepsis
• Virulence factors

Streptococcus agalactiae is a major neonatal pathogen. Disease progression is characterised by bacterial adaptation from commensal maternal vaginal colonisation to environments associated with neonatal disease, including exposure to blood. To explore this adaptation in vitro, we have used proteomics to identify proteins differentially expressed following growth on Todd Hewitt agar in the presence or absence of 10% v/v human serum. Twelve differentially expressed proteins were identified. Notably, the C protein beta antigen and arginine deiminase proteins were upregulated following growth in the presence of human serum, consistent with previous studies implicating these two proteins in the pathogenesis of S. agalactiae disease.

• 出版日期2011-8