Abnormal vascular architecture at the placental-maternal interface in placenta increta

作者：Chantraine Frederic^*; Blacher Silvia; Berndt Sarah; Palacios Jaraquemada Jose; Sarioglu Nanette; Nisolle Michelle; Braun Thorsten; Munaut Carine; Foidart Jean Michel

来源：American Journal of Obstetrics and Gynecology, 2012, 207(3): 188.e1.

DOI：10.1016/j.ajog.2012.06.083

• placenta increta
• placental bed
• vessel architecture
• virtual imaging

OBJECTIVE: The objective of the study was to characterize the vascular architecture at the placental-maternal interface in pregnancies complicated by placenta increta and normal pregnancies. %26lt;br%26gt;STUDY DESIGN: Vessel numbers and cross-section area density and spatial and area distributions in 13 placenta-increta placental beds were compared with 9 normal placental beds using computer-assisted image analysis of whole-slide CD31 immunolabeled sections. %26lt;br%26gt;RESULTS: The total areas occupied by vessels in normal and placentaincreta placental beds were comparable, but vessels were significantly sparser and larger in the latter. Moreover, placenta-increta-vessel distributions (area and distance from the placental-myometrial junction) were more heterogeneous. %26lt;br%26gt;CONCLUSION: Size and spatial organization of the placenta-increta vascular architecture at the placental-maternal interface differed from normal and might partially explain the severe hemorrhage observed during placenta-increta deliveries.

• 出版日期2012-9