Nickel-catalysed C-O bond reduction of 2,4,6-triaryloxy-1,3,5-triazines in 2-methyltetrahydrofuran

作者：Wang, Yaoyao; Shen, Jun; Chen, Qun; Wang, Liang^*; He, Mingyang^*

来源：Chinese Chemical Letters, 2019, 30(2): 409-412.

DOI：10.1016/j.cclet.2018.09.009

• Nickel catalysis
• Phenol derivatives
• C-O bond cleavage
• Green solvent

A nickel-catalysed reduction of phenol derivatives activated by 2,4,6-trichloro-1,3,5-triazine (TCT) in ecofriendly 2-methyltetrahydrofuran (2-MeTHF) is described. The phenol-TCT derivatives were readily prepared using grinding method in short time without further purification. This catalytic system allowed the facile C-O cleavage of phenol-TCT derivatives under mild reaction conditions with high efficiency and good functional group tolerance. Gram-scale reaction was also achieved. Particularly, sequential functionalization of phenol TCT derivatives followed by C-O bond reduction could also be realized, affording the high value-added products in moderate to good yields.

• 出版日期2019-2
• 单位常州大学