Age-related changes in prostate zonal volumes as measured by high-resolution magnetic resonance imaging (MRI): a cross-sectional study in over 500 patients

作者：Turkbey, Baris; Huang, Robert; Vourganti, Srinivas; Trivedi, Hari; Bernardo, Marcelino; Yan, Pingkun; Benjamin, Compton; Pinto, Peter A.; Choyke, Peter L.^*

来源：BJU International, 2012, 110(11): 1642-1647.

DOI：10.1111/j.1464-410X.2012.11469.x

• BPH
• MRI
• prostate zonal volumes
• age-related changes

OBJECTIVE
To use ability of magnetic resonance imaging (MRI) to investigate age-related changes in zonal prostate volumes.
PATIENTS AND METHODS
This Institutional Review Board approved, Health Insurance Portability and Accountability Act-compliant study consisted of 503 patients who underwent 3 T prostate MRI before any treatment for prostate cancer.
Whole prostate (WP) and central gland (CG) volumes were manually contoured on T2-weighted MRI using a semi-automated segmentation tool. WP, CG, peripheral zone (PZ) volumes were measured for each patient.
WP, CG, PZ volumes were correlated with age, serum prostate-specific antigen (PSA) level, International Prostate Symptom Score (IPSS), Sexual Health Inventory for Men (SHIM) scores.
RESULTS
Linear regression analysis showed positive correlations between WP, CG volumes and patient age (P < 0.001); there was no correlation between age and PZ volume (P= 0.173).
There was a positive correlation between WP, CG volumes and serum PSA level (P < 0.001), as well as between PZ volume and serum PSA level (P= 0.002).
At logistic regression analysis, IPSS positively correlated with WP, CG volumes (P < 0.001).
SHIM positively correlated with WP (P= 0.015) and CG (P= 0.023) volumes.
As expected, the IPSS of patients with prostate volumes (WP, CG) in first decile for age were significantly lower than those in tenth decile.
CONCLUSIONS
Prostate MRI is able to document age-related changes in prostate zonal volumes.
Changes in WP and CG volumes correlated inversely with changes in lower urinary tract symptoms.
These findings suggest a role for MRI in measuring accurate prostate zonal volumes; have interesting implications for study of age-related changes in the prostate.

• 出版日期2012-12
• 单位中国科学院西安光学精密机械研究所; 瞬态光学与光子技术国家重点实验室