Aquaporins and their implications in metabolism

作者：Rodriguez Amaia; Catalan Victoria; Becerril Sara; Sainz Neira; Salvador Javier; Gomez Ambrosi Javier; Fruhbeck Gema^*

来源：Obesity and Metabolism-Milan, 2007, 3(2): 58-67.

• human physiology and disease
• knockout mice
• water/glycerol transporters

Aquaporins (AQPs) are water channels that facilitate a rapid transport of water across cell membranes. In some cases, these pores are also permeated by small solutes, particularly glycerol. Thirteen aquaporins (AQP0-12) have been identified so far in mammalian tissues. AQPs participate in many physiological and pathophysiological processes that include renal water absorption, neuro-homeostasis, digestion, tumour angiogenesis, fat metabolism and reproduction. Better understanding of the exact mechanisms and regulation of AQPs might be useful for designing potential drug targets against different metabolic disorders, such as stroke, glaucoma, brain oedema, cancer and obesity

• 出版日期2007-6