科研之友
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摘要
Hypertriglyceridemia (HTG) is an important feature of lipid metabolism abnormality in patients with type 2 diabetes mellitus (T2DM). Apolipoprotein A5 (apoA5) is positively correlated with triglycerides (TG) and insulin resistance (IR). However, its relationship with TG in humans is still controversial till now. Further, its exact mechanism in TG reducing also remains unclear. Meanwhile, adiponectin (APN) can also inhibit TG in humans. Whether there is any association between apoA5 and APN in TG inhibition remains to be explored. This study was taken to investigate the relationships among apoA5, TG, APN and IR in patients with impaired glucose regulation (IGR) and T2DM, the levels of apoA5, TG and APN in the plasma were detected in the current study. Thirty five patients with newly-diagnosed T2DM (T2DM group), 30 patients with IGR (IGR group), and 35 sex- and age-matched normal controls (NGT group) were studied. All the subjects underwent an intravenous glucose tolerance test (IVGTT). Fasting apoA5 and APN were detected by an enzyme linked immunosorbent assay (ELISA). Fasting free fatty acid was measured using colorimetry. Homeostasis model assessment of insulin resistance (HOMA-IR) was made. The plasmic apoA5 and APN levels in the T2DM and IGR groups were lower than that in the NGT group. Furthermore, the levels of apoA5 and APN in the T2DM group were lower than those in IGR group (P < 0.05). ApoA5 was negatively correlated with TG, FFA, 2hFFA, LDL-C, FPG, 2hPG, FINS, HOMA-IR, BMI, and WHR, but positively correlated with APN and HDL-C. The multiple linear regression analysis showed TG, APN, FFA, WHR and HOMA-IR were independent factors of apoA5. Down-regulated apoA5 and APN has a synergistic effect in the process from NGT to IGR and then to T2DM. They can increase FFA expression through participating in the occurrence and development of HTG and IR.
- 出版日期2013-3
- 单位重庆医科大学
