HER-3 expression in HER-2-amplified breast carcinoma

作者：Czopek Jacek; Pawlega Janusz^*; Fijorek Kamil; Pueskuellueoglu Miroslawa; Rozanowski Pawel; Okon Krzysztof

来源：Wspolczesna Onkologia-Contemporary Oncology, 2013, 17(5): 446-449.

DOI：10.5114/wo.2013.38564

• breast cancer
• HER-2
• HER-3
• immunohistochemistry
• prognostic factor

Aim of the study: To determine whether the expression of HER-3 influences the survival of HER-2 positive patients with breast cancer (BC). %26lt;br%26gt;Material and methods: In the present work, the expression of HER-3 in a group of 35 HER-2 positive patients with BC was studied by performing immunohistochemistry (IHC) in formalin-fixed paraffin embedded tissues. %26lt;br%26gt;Results: Higher HER-3 status if estimated by IHC correlated significantly with older age of the patients HER-3 expression did not correlate with estrogen or progesterone receptor status, pT or pN. There was also no significant difference in disease-free or overall survival (DFS and OS) between groups with different HER-3 expression, although some tendencies were seen as HER-3 expression in over 50% of cells was a factor of worse 5- and 10-year survival. %26lt;br%26gt;Conclusions: Further studies should be performed on a larger group of patients to confirm the prognostic role of HER-3 status determined by IHC in BC.

• 出版日期2013-10