Asymmetric meso-aziridine ring-opening reactions using a chiral zirconium catalyst

作者：Seki Kazutaka; Yu Rongmin; Yamazaki Yumi; Yamashita Yasuhiro; Kobayashi Shu^*

来源：Chemical Communications, 2009, (38): 5722-5724.

DOI：10.1039/b914271c

A chiral zirconium catalyst prepared from Zr(O(t)Bu)(4) and a chiral tridentate BINOL was found to be effective for asymmetric meso-aziridine ring-opening reactions with aniline derivatives. The N-benzhydryl group on the product obtained was easily cleaved to give the corresponding amine in high yield under reductive conditions.

• 出版日期2009