Anti-photoaging Effects of 2-Methoxy-5-(2-methyl propyl) Pyrazine Isolated from Peach (Prunus persica (L.) Batsch)

作者：Han Sunghwa; Park Kwang Kyun; Chung Won Yoon; Lee Sang Kook; Kim Jaekyung; Hwang Jae Kwan^*

来源：Food Science and Biotechnology, 2010, 19(6): 1667-1671.

DOI：10.1007/s10068-010-0236-2

• photoaging
• 2-methoxy-5-(2-methyl propyl) pyrazine
• matrix metalloproteinase-1
• type-1 procollagen

In this study, antioxidant and anti-photoaging activities of 2-methoxy-5-(2-methyl propyl) pyrazine (MMPP) isolated from peach (Prunus persica (L.) Batsch) were investigated in terms of matrix metalloproteinase (MMP)-1 and type-1 procollagen expression in ultraviolet (UV)-irradiated human skin fibroblasts. MMPP was obtained from the butanol fraction of a 95% ethanol extract of peach. The antioxidant and anti-photoaging activity of MMPP were assessed by 1,1-diphenyl-2-picrylhydrazy (DPPH), Western blot, and reverse trans-cription-polymerase chain reaction (RT-PCR) analyses. MMPP displayed radical scavenging activity, suppressed MMP-1 expression, and increased type-1 procollagen expression. These results support the use of MMPP from peach as an anti-photoaging compound.

• 出版日期2010-12