Adjuvant radiotherapy for pancreatic cancer: rationale and results

作者：Hitchcock Kathryn; Rutenberg Michael S^*

来源：Translational Cancer Research, 2015, 4(6): 676-683.

DOI：10.3978/j.issn.2218-676X.2015.12.07

• Radiotherapy
• radiation therapy
• pancreas cancer
• gastrointestinal cancer
• adjuvant therapy

Pancreatic cancer is a highly aggressive disease with a poor prognosis. The mainstay of curative treatment remains surgical resection. Adjuvant chemotherapy has been clearly shown to improve survival. Yet because local-regional recurrence after surgery is the predominant pattern of failure, chemoradiation is often used as a component of treatment. Despite several prospective, randomized trials evaluating adjuvant chemoradiation, controversy persists as to whether it confers a survival benefit. Here we review the rationale for adjuvant chemoradiation and the results of the major studies evaluating the impact of postoperative radiotherapy on disease control and patient survival.

• 出版日期2015-12