Cooperative Melting in Caged Dimers with Only Two DNA Duplexes

作者：Eryazici Ibrahim; Prytkova Tatiana R; Schatz George C^*; Nguyen SonBinh T

来源：Journal of the American Chemical Society, 2010, 132(48): 17068-17070.

DOI：10.1021/ja107232x

Small molecule DNA hybrids with only two parallel DNA duplexes (rSMDH(2)) displayed sharper melting profiles compared to unmodified DNA duplexes, consistent with predictions from neighboring-duplex theory. Using adjusted thermodynamic parameters obtained from a coarse-grain dynamic simulation, the experimental data fit well to an analytical model.

• 出版日期2010-12-8
• 单位西北大学