New Triterpenoid Saponin C-20 Epimers from the Alkaline-Degradation Products of Ginsenoside Re and Their Cytotoxic Activities

作者：Ding, Hongda; Wang, Zhicai; Chen, Xia; Zhang, Pengfei; Xu, Fangfei; Xu, Yan; Li, Manman; Chen, Yanping^*

来源：Chemistry of Natural Compounds, 2018, 54(3): 490-495.

DOI：10.1007/s10600-018-2386-z

• alkaline-degradation
• ginsenoside Re
• new triterpenoid saponins
• cytotoxic activities

Nine compounds, including two new triterpenoid saponin C-20 epimers (4 and 5) and seven known ginsenosides (1-3, 6-9), have been isolated and purified from the alkaline-degradation products of ginsenoside Re. Their structures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR and HR-ESI-MS. Among them, (20S,22E)-6-O-beta-D-glucopyranosyl-dammar-22(23),24-diene-3 beta,6 alpha,12 beta-triol (4) and (20R,22E)-6-O-beta-D-glucopyranosyl-dammar-22(23),24-diene-3 beta,6 alpha,12 beta-triol (5) were identified as new triterpenoid saponins and they were assayed for cytotoxic activities against five human tumor cell lines.

• 出版日期2018-5
• 单位吉林大学