Alpha-Tocopherol Concentration in Colostrum and Serum of Women With Premature Labor

作者：Pires Medeiros Jeane Franco; da Silva Ribeiro Rodrigues Karla Danielly; Rosa Lima Mayara Santa; Cortes da Silva Anna Larissa; Carvalho de Queiroz Jaluza Luana; Dimenstein Roberto

来源：Journal of Pediatric Gastroenterology and Nutrition, 2016, 62(2): 348-352.

DOI：10.1097/MPG.0000000000000969

• maternal
• milk
• prematurity
• vitamin E

Objective:The aim of the study was to evaluate and compare the levels of alpha-tocopherol in colostrum milk and serum of mothers with premature birth, classified as severe prematurity and moderate prematurity.Methods:Cross-sectional study with 65 women, 18 births classified as severe prematurity (<32 weeks of gestation) and 47 as moderate prematurity (32 weeks of gestation). The study only included mothers without any conditions associated with pregnancy and who had a single conception without any malformation. Samples of serum and colostrum were collected during fasting in the immediate postpartum, and alpha-tocopherol was analyzed by high-performance liquid chromatography. To determine the biochemical nutritional status of vitamin E, a serum cutoff (11.6 mol/L) was adopted. The Student t test for independent variables compared the average concentrations of alpha-tocopherol in serum and colostrum among prematurity groups. Differences were considered significant when P<0.05.Results:The alpha-tocopherol concentrations in colostrum were similar in both groups, being 34.520.2 mol/L for women with severe prematurity and 35.1 +/- 16.3 mol/L for moderate prematurity. For the serum of puerperal women with severe prematurity, alpha-tocopherol concentration was, however, lower than in women with moderate prematurity, 22.2 +/- 4.4 mol/L versus 27.1 +/- 8.6 mol/L (P<0.05). The serum levels of alpha-tocopherol indicated nutritional risk at 5.6% (n=1) of women with severe prematurity and 4.3% (n=2) for those with moderate prematurity.Conclusions:Severe prematurity affected the levels of alpha-tocopherol in maternal serum; however, the level of prematurity did not change the concentration of vitamin E in colostrum.

• 出版日期2016-2