Anticonvulsant and neurotoxicity profile of the rhizome of Smilax china Linn. in mice

作者：Vijayalakshmi A^*; Ravichandiran V; Anbu J; Velraj Malarkodi; Jayakumari S

来源：Indian Journal of Pharmacology, 2011, 43(1): 27-30.

DOI：10.4103/0253-7613.75662

• Epilepsy
• China root
• Smilax china
• neurotoxicity

Objective : To study the anticonvulsant activity and neurotoxicity of ethanolic extract and ethyl acetate fraction of the rhizome of Smilax china (EESC and EAF, respectively) in mice. Materials and Methods : The anticonvulsant activities of EESC and EAF were studied against maximal electroshock (MES) and pentylenetetrazole (PTZ)-induced seizures in mice and neurotoxicity was determined using rotarod test. Results : The duration of hindleg extension in MES test was reduced significantly (P < 0.001) by EESC at a dose level of 400 mg/kg and EAF at both higher dose levels (200 and 400 mg/kg). In PTZ model, the seizure latency was prolonged by all the test groups. Conclusion : The EESC and EAF may help to control petit mal and grand mal seizures.

• 出版日期2011-2