Atorvastatin protects against cerebral ischemia/reperfusion injury through anti-inflammatory and antioxidant effects

作者：Tu, Qiuyun; Cao, Hui; Zhong, Wei; Ding, Binrong; Tang, Xiangqi^*

来源：Neural Regeneration Research, 2014, 9(3): 268-275.

DOI：10.4103/1673-5374.128220

• nerve regeneration
• brain injury
• cerebral ischemia/reperfusion
• atorvastatin
• E-selectin
• myeloperoxidase
• superoxide dismutase
• malondialdehyde
• inflammation
• free radicals
• blood-brain barrier
• stroke
• NSFC grant
• neural regeneration

In addition to its lipid-lowering effect, atorvastatin exerts anti-inflammatory and antioxidant effects as well. In this study, we hypothesized that atorvastatin could protect against cerebral ischemia/reperfusion injury. The middle cerebral artery ischemia/reperfusion model was established, and atorvastatin, 6.5 mg/kg, was administered by gavage. We found that, after cerebral ischemia/reperfusion injury, levels of the inflammation-related factors E-selectin and myeloperoxidase were upregulated, the oxidative stress-related marker malondialdehyde was increased, and superoxide dismutase activity was decreased in the ischemic cerebral cortex. Atorvastatin pretreatment significantly inhibited these changes. Our findings indicate that atorvastatin protects against cerebral ischemia/reperfusion injury through anti-inflammatory and antioxidant effects.

• 出版日期2014-2
• 单位中南大学