Association of subungual melanoma and subungual squamous cell carcinoma: A case series

作者：Boespflug Amelie; Debarbieux Sebastien; Depaepe Lauriane; Chouvet Brigitte; Maucort Boulch Delphine; Dalle Stephane; Balme Brigitte; Thomas Luc^*

来源：Journal of the American Academy of Dermatology, 2018, 78(4): 760-768.

DOI：10.1016/j.jaad.2017.09.038

• association
• confocal microscopy
• dermatopathology
• dermoscopy
• squamomelanocytic tumor
• subungual epidermoid carcinoma
• subungual melanoma
• subungual squamous cell carcinoma
• SSCC
• SUM

Background: Subungual squamous cell carcinoma (SSCC) and subungual melanoma (SUM) are rare tumors. Several case reports of association of SSCC with SUM (SSCC-SUM) have been published.
Objective: We sought to document the clinical, dermoscopic, and histologic features in a case series of SSCC-SUMs and describe their relative frequency compared with those of SSCC and SUM.
Methods: All patients who underwent surgical exploration of the nail apparatus with a dermatopathologic examination from 2012 to 2015 were reviewed retrospectively to identify all cases of SSCC, SUM, and SSCC-SUM. For patients with SSCC-SUM, clinical characteristics were obtained from electronic medical records. All histologic specimens were reviewed by 3 dermatopathologists.
Results: The medical records of 456 patients were reviewed. SSCC was diagnosed in 78 (17%), SUM was diagnosed in 63 (14%), and SSCC-SUM was diagnosed in 9. Patients with SSCC-SUM accounted for 11% of those with a diagnosis of SSCC (9 of 78) and 14% of those with a diagnosis of SUM (9 of 63).
Limitations: This was a single-institution retrospective study.
Conclusion: The association of SSCC and SUM is relatively frequent in patients with SUM and warrants further consideration to understand the underlying mechanisms involved. (J Am Acad Dermatol 2018;78:760-8.)

• 出版日期2018-4