Phenyliodine Diacetate-Mediated Intramolecular C(sp(2))-H Amidation for 1,2-Disubstituted Benzimidazole Synthesis under Metal-Free Conditions

作者：Maiti Saikat; Mal Prasenjit^*

来源：Advanced Synthesis & Catalysis, 2015, 357(7): 1416-1424.

DOI：10.1002/adsc.201401110

• benzimidazole synthesis
• C-H amidation
• hypervalent iodine
• metal-free synthesis
• phenyliodine diacetate (PIDA)

A transition metal-free, hypervalent iodine(III) reagent [phenyliodine diacetate (PIDA)]-mediated C(sp(2))-H amidation in trifluoroethanol (TFE) has been developed. The intramolecular coupling methodology presented here provides a direct access to 1,2-disubstituted multifunctional benzimidazoles in good to excellent yields. The reactions were performed in the open air and at ambient temperature, and were found to be eco-friendly and atom-economical.

• 出版日期2015-5-4