Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma

作者：Lawrie Charles H^*; Gal Shira; Dunlop Heather M; Pushkaran Beena; Liggins Amanda P; Pulford Karen; Banham Alison H; Pezzella Francesco; Boultwood Jacqueline; Wainscoat James S; Hatton Christian S R; Harris Adrian L

来源：British Journal of Haematology, 2008, 141(5): 672-675.

DOI：10.1111/j.1365-2141.2008.07077.x

• microRNA
• diffuse large B-cell lymphoma
• lymphoma
• sera
• plasma

Circulating nucleic acids have been shown to have potential as non-invasive diagnostic markers in cancer. We therefore investigated whether microRNAs also have diagnostic utility by comparing levels of tumour-associated MIRN155 (miR-155), MIRN210 (miR-210) and MIRN21 (miR-21) in serum from diffuse large B-cell lymphoma (DLBCL) patients (n = 60) with healthy controls (n = 43). Levels were higher in patient than control sera (P = 0.009, 0.02 and 0.04 respectively). Moreover, high MIRN21 expression was associated with relapse-free survival (P = 0.05). This is the first description of circulating microRNAs and suggests that microRNAs have potential as non-invasive diagnostic markers for DLBCL and possibly other cancers.

• 出版日期2008-6