Antimicrobial and Cytotoxic Activities of Malaysian Endophytes

作者：Ramasamy Kalavathy^*; Lim Siong Meng; Abu Bakar Hamidah; Ismail Noorliana; Ismail Maria Suhana; Ali Muhamad Fuad; Weber Jean Frederic Faizal; Cole Anthony L J

来源：Phytotherapy Research, 2010, 24(5): 640-643.

DOI：10.1002/ptr.2891

• endophytes
• anticancer
• cytotoxic
• antimicrobial

Endophytes, which are receiving increasing attention, have been found to be potential sources of bioactive metabolites following the discovery of paclitaxel producing endophytic fungi. In the present study, a total of 348 endophytes were isolated from different parts of 24 Malaysian medicinal plants. Three selected endophytes (HAB10R12, HAB11R3 and HAB21F25) were investigated for their antimicrobial and cytotoxic activities. For antimicrobial activity, HAB10R12 and HAB11R3 were found to be most active against bacteria and fungi, respectively. Their antimicrobial effects were comparable to, if not better than, a number of current commercial antibacterial and antifungal agents. Both HAB10R12 and HAB21F25 were found to be potential anticancer drug candidates, having potent activity against MCF-7 and HCT116 cell lines and warrant further investigation.

• 出版日期2010-5