Mining diverse small RNA species in the deep transcriptome

作者：Vickers Kasey C^*; Roteta Leslie A; Hucheson Dilks Holli; Han Leng; Guo Yan

来源：TRENDS IN BIOCHEMICAL SCIENCES, 2015, 40(1): 4-7.

DOI：10.1016/j.tibs.2014.10.009

• small RNA
• RNA sequencing
• long-noncoding RNA
• transcriptome
• microRNA
• high-throughput sequencing
• data analysis

Transcriptomes of many species are proving to be exquisitely diverse, and many investigators are now using high-throughput sequencing to quantify non-protein-coding RNAs, namely small RNAs (sRNA). Unfortunately, most studies are focused solely on microRNA changes, and many investigators are not analyzing the full compendium of sRNA species present in their large datasets. We provide here a rationale to include all types of sRNAs in sRNA sequencing analyses, which will aid in the discovery of their biological functions and physiological relevance.

• 出版日期2015-1