An efficient acetylation of dextran using in situ activated acetic anhydride with iodine

作者：Hussain Muhammad A^*; Shahwar Dure; Tahir Muhammad N; Sher Muhammad; Hassan Muhammad N; Afzal Zakia

来源：Journal of the Serbian Chemical Society, 2010, 75(2): 165-173.

DOI：10.2298/JSC1002165H

• acetic anhydride
• acetylation
• dextran
• iodine
• polysaccharide

A facile, efficient, cost-effective and solvent-free acetylation method has been developed for the acetylation of dextran. Dextran acetates were successfully synthesized using different molar ratios of acetic anhydride in the presence of iodine as a catalyst Without the use of any solvent. The reactions were realized at 50 degrees C for 3 h under stirring and nitrogen. This efficient method yielded highly pure and organosoluble dextran esters. The reaction appears highly effective for obtaining higher degrees of substitution (DS) with great efficiency. Under solvent-free conditions, dextran triacetates were efficiently synthesized. It was also observed that the molar ratio can easily control the DS of pendant groups onto the polymer backbone. Hence, a range of products With varying DS were Successfully designed, purified and characterized. Covalent attachment of the pendant groups onto the polymer backbone was verified by spectroscopic techniques. Thermogravimetric analysis indicated that the obtained dextran esters were thermally its stable as dextran. The DS of the pendant groups onto the polymer backbone was calculated using standard acid base titration after saponification. Furthermore, all products were thoroughly characterized by thermal analysis (TG and DTG), and FT-IR and (1)H-NMR spectroscopic analysis.

• 出版日期2010