Alkaloids from Boophone haemanthoides (Amaryllidaceae)

作者：Nair Jerald J; Rarova Lucie; Strnad Miroslav; Bastida Jaume; van Staden Johannes^*

来源：Natural Product Communications, 2013, 8(12): 1705-1710.

DOI：10.1177/1934578x1300801211

• Alkaloid
• Amaryllidaceae
• Boophone haemanthoides
• Distichaminol

In this study, the South African Amaryllid Boophone haemanthoides was examined for its phytochemical composition and cytotoxicity. In the process eight alkaloid structures, including the new compound distichaminol, were identified in bulb ethanolic extracts. Of the isolates, lycorine and distichamine exhibited strong activities against human acute lymphoblastic leukemia (CEM), breast adenocarcinoma (MCF7) and cervical adenocarcinoma (HeLa) cells with IC(50)s ranging from 1.8 to 9.2 mu M.

• 出版日期2013-12