Garlicnin A from the Fraction Regulating Macrophage Activation of Allium sativum

作者：El Aasr Mona; Fujiwara Yukio; Takeya Motohiro; Ono Masateru; Nakano Daisuke; Okawa Masafumi; Kinjo Junei; Ikeda Tsuyoshi; Miyashita Hiroyuki; Yoshimitsu Hitoshi; Nohara Toshihiro^*

来源：CHEMICAL & PHARMACEUTICAL BULLETIN, 2011, 59(11): 1340-1343.

DOI：10.1248/cpb.59.1340

• Allium sativum
• sulfoxide
• garlicnin A
• macrophage activation

Garlicnin A (1), a new stable, sulfur-containing compound isolated from a fraction of the acetone extracts of Allium sativum L. garlic bulbs, showed the potential to suppress tumor cell proliferation by inhibiting the polarization of M2 alternatively activated macrophages, and its structure was characterized as 3,4-dimethyl-5-(4,5-dithia-1E,7-octadiene)-tetrahydrothiophene-2-sulfoxide-S-oxide, on the basis of the results of spectroscopic analysis results.

• 出版日期2011-11