An Efficient Synthesis of 3,4-Dihydro-3-substituted-2H-naphtho[2,1-e][1,3]oxazine Derivatives Catalyzed by Zirconyl(IV) Chloride and Evaluation of its Biological Activities

作者：Kategaonkar Amol H; Sonar Swapnil S; Pokalwar Rajkumar U; Kategaonkar Atul H; Shingate Bapurao B; Shingare Murlidhar S^*

来源：Bulletin of the Korean Chemical Society, 2010, 31(6): 1657-1660.

DOI：10.5012/bkcs.2010.31.6.1657

• 1,3-Oxazines
• Zirconyl(IV) chloride
• Grinding
• Antibacterial
• Antifungal

An efficient and novel one-pot synthesis of new 3,4-dihydro-3-substituted-2H-naphtho[2,1-e][1,3]oxazine derivatives from 1-naphthol, various anilines and formalin at room temperature grinding is presented. The six-membered N,O-heterocyclic skeleton was constructed via zirconyl(IV) chloride promoted Mannich type reaction. In vitro antimicrobial activities of synthesized compounds have been investigated against Gram-positive Bacillus subtilis, Gram negative Escherichia coli and two fungi Candida albicans and Aspergillus niger in comparison with standard drugs. The results of preliminary bioassay indicate that some of title compounds possess significant antibacterial and anti fungal activity.

• 出版日期2010-6-20