A multi-institutional analysis of intraoperative radiotherapy for early breast cancer: Does age matter?

作者：Abbott A M; Valente S A; Loftus L; Tendulkar R D; Greif J M; Bethke K P; Donnelly E D; Lottich C; Ross D L; Friedman N B; Bedi C G; Joh J E; Kelemen P; Hoefer R A; Kang S K; Ruffer J; Police A; Fyles A; Graves G M; Willey S C; Tousimis E A; Small W; Lyons J; Grobmyer S; Laronga C^*

来源：American Journal of Surgery, 2017, 214(4): 629-633.

DOI：10.1016/j.amjsurg.2017.06.018

Background: Single-session intraoperative radiation therapy (IORT) minimizes treatment demands associated with traditional whole breast radiation therapy (WBRT) but outcomes on local disease control and morbidity among the elderly is limited.
Methods: A multi-institutional retrospective registry was established from 19 centers utilizing IORT from 2007 to 2013. Patient, tumor, and treatment variables were analyzed for ages < 70 and >= 70.
Results: We evaluated 686 patients (< 70 - 424; >= 70 -262) who were margin and lymph node negative. Patients < 70 were more likely to have longer operative time, oncoplastic closure, higher rates of IORT used as planned boost, and receive chemotherapy and post-operative WBRT. Wound complication rates were low and not significantly different between age groups. Median follow-up was 1.06 (range 0.51-1.9) years for < 70 and 1.01 (range 0.5-1.68) years for >= 70. There were 5 (0.73%) breast recurrences (4 in < 70 and 1 >= 70, p = 0.65) and no axillary recurrences during follow-up.
Conclusions: IORT was associated with a low rate of wound complication and local recurrence on short-term follow-up in this cohort.

• 出版日期2017-10