Bone loss in chronic kidney disease: Quantity or quality?

作者：Zheng Cai Mei; Zheng Jin Quan; Wu Chia Chao; Lu Chien Lin; Shyu Jia Fwu; Yung Ho Hsu; Wu Mei Yi; Chiu I Jen; Wang Yuan Hung; Lin Yuh Feng; Lu Kuo Cheng

来源：Bone, 2016, 87: 57-70.

DOI：10.1016/j.bone.2016.03.017

• Chronic kidney disease-mineral bone disorder (CKD-MBD)
• Bone quantity and bone quality losses
• Bone remodeling
• Vitamin D therapy

Chronic kidney disease (CKD) patients experience bone loss and fracture because of a specific CKD-related systemic disorderknown as CKD-mineral bone disorder (CKD-MBD). The bone turnover, mineralization, and volume (TMV) system describes the morphological bone lesions in renal osteodystrophy related to CKD-MBD. Bone turnover and bone volume are defined as high, normal, or low, and bone mineralization is classified as normal or abnormal. All types of bone histology related to TMV are responsible for both bone quantity and bone quality losses in CKD patients. This review focuses on current bone quantity and bone quality losses in CKD patients and finally discusses potential therapeutic measures.

• 出版日期2016-6