A new secoiridoid glycoside and a new sesquiterpenoid glycoside from Valeriana jatamansi with neuroprotective activity

作者:Tan, Yu-Zhu; Yong, Yan; Dong, Yan-Hong; Wang, Ru-Jing; Li, Hong-Xiang; Zhang, Hai; Guo, Da-Le; Zhang, Shi-Jin; Dong, Xiao-Ping*; Xie, Xiao-Fang*
来源:Phytochemistry Letters, 2016, 17: 177-180.
DOI:10.1016/j.phytol.2016.07.020

摘要

A new secoiridoid glycoside, isopatrinioside (1) and a new sesquiterpenoid glycoside, valeriananoid F (2), together with nine known compounds, were isolated from the roots of Valeriana jatamansi. Their structures were elucidated on the basis of spectroscopic analysis. Compound 1 was an unusual monocyclic iridoid glycoside ring-opened between C-1 and C-2 produced by the cleavage of the pyran ring. Of the eleven isolates, compounds 1 and 4 exhibited moderate neuroprotective effects against CoCl2-induced neuronal cell death in PC12 cells.