Monitoring of microenvironmental changes in the major and minor grooves of DNA by dan-modified oligonucleotides

作者：Kimura T; Kawai K; Majima T^*

来源：Organic Letters, 2005, 7(26): 5829-5832.

DOI：10.1021/ol052473m

We describe the synthesis of new environmentally sensitive fluorescence probes to elucidate DNA structures. DNA oligonucleotides containing fluorophore dan (6-(dimethylamino)-2-acylnaphthalene)-modified dC or dG were able to monitor the microenvironmental changes in both the major and minor grooves of DNA with a B- to A-DNA conformational transition and RNA hybridization.

• 出版日期2005-12-22