Adaptive cytokine production in early life differentially predicts total IgE levels and asthma through age 5 years

作者：Rothers Janet; Halonen Marilyn; Stern Debra A; Lohman I Carla; Mobley Sara; Spangenberg Amber; Anderson Dayna; Wright Anne L^*

来源：Journal of Allergy and Clinical Immunology, 2011, 128(2): 397-U422.

DOI：10.1016/j.jaci.2011.04.044

• Asthma
• IgE
• cytokines
• IL-4
• IL-5
• IL-13
• IFN-gamma
• children

Background: Although it has been postulated that allergic disease is associated with a predominance of T(H)2 cells, whether IgE levels and asthma might differ in their relation to early-life cytokine production is not known.
Objective: We sought to assess the relationship between first-year adaptive immune cytokine production with asthma and total IgE levels through age 5 years in a nonselected birth cohort.
Methods: Mitogen (concanavalin A/phorbol 12-myristate 13-acetate)-stimulated IL-4, IL-5, IL-13, and IFN-gamma levels were measured in supernatants from cord blood mononuclear cells and PBMCs at birth, 3 months, and 12 months. Total serum IgE levels and physician-diagnosed active asthma were assessed at 1, 2, 3, and 5 years. Longitudinal models that adjust for both T(H)1 and T(H)2 cytokine production were used to determine relations of outcomes.
Results: Relations of cytokines to total IgE levels and asthma were strikingly different. Total IgE levels through age 5 years were positively associated with 12-month IL-4 (P < .001), IL-5 (P < .001), and IL-13 (P = .02) levels when adjusted for IFN-gamma levels and inversely associated with 12-month IFN-gamma levels after IL-4 adjustment (P = .01). Active asthma through age 5 years was positively associated with 3-month IL-13 levels adjusted for IFN-gamma (odds ratio, 2.6; P < .001) and inversely associated with 3-month IFN-gamma levels adjusted for IL-13 (odds ratio, 0.5; P = .001). These relations were strongest for nonatopic asthma.
Conclusion: Total IgE levels and active asthma through age 5 years are associated with adaptive cytokine production in early life, although relations vary temporally and with regard to the relative importance of individual cytokines. (J Allergy Clin Immunol 2011;128:397-402.)

• 出版日期2011-8