Dosimetric characterization and commissioning of a superficial electronic brachytherapy device for skin cancer treatment

作者：Park Han Beom; Kim Hyun Nam; Lee Ju Hyuk; Lee Ik Jae; Choi Jinhyun; Cho Sung Oh^*

来源：Nuclear Engineering and Technology, 2018, 50(6): 937-943.

DOI：10.1016/j.net.2018.04.007

• Carbon Nanotube
• Electronic Brachytherapy
• Miniature X-ray Tube
• Radiotherapy Experiments
• Skin Cancer

Background: This work presents the performance of a novel electronic brachytherapy (EBT) device and radiotherapy (RT) experiments on both skin cancer cells and animals using the device.
Methods and materials: The performance of the EBT device was evaluated by measuring and analyzing the dosimetric characteristics of X-rays generated from the device. The apoptosis of skin cancer cells was analyzed using B16F10 melanoma cancer cells. Animal experiments were performed using C57BL/6 mice.
Results: The X-ray characteristics of the EBT device satisfied the accepted tolerance level for RT. The results of the RT experiments on the skin cancer cells show that a significant apoptosis induction occurred after irradiation with 50 kVp X-rays generated from the EBT device. Furthermore, the results of the animal RT experiments demonstrate that the superficial X-rays significantly delay the tumor growth and that the tumor growth delay induced by irradiation with low-energy X-rays was almost the same as that induced by irradiation with a high-energy electron beam.
Conclusions: The developed new EBT device has almost the same therapeutic effect on the skin cancer with a conventional linear accelerator. Consequently, the EBT device can be practically used for human skin cancer treatment in the near future.

• 出版日期2018-8