An elegant protocol for the synthesis of N-substituted pyrroles through C-N cross coupling/aromatization process using CuFe2O4 nanoparticles as catalyst under ligand-free conditions

作者：Satish G; Reddy K Harsha Vardhan; Ramesh K; Kumar B S P Anil; Nageswar Y V D^*

来源：Tetrahedron Letters, 2014, 55(16): 2596-2599.

DOI：10.1016/j.tetlet.2014.01.075

• N-substituted pyrrole
• Iodo benzene/benzyl bromide
• CuFe2O4 nanoparticles
• C-N cross-coupling
• Magnetically separable
• Recyclability

A simple and efficient, ligand-free C-N cross-coupling of aryl halides/benzyl bromides with trans-4-hydroxy-L-proline has been developed to produce aromatized N-substituted pyrroles, using a catalytic amount of magnetically separable and recyclable CuFe2O4 nanoparticles, in the presence of Cs2CO3 in DMSO at 100 degrees C.

• 出版日期2014-4-16