Antidepressant Treatment with Venlafaxine and Mirtazapine: no Effect on Serum Concentration of Vascular Endothelial Growth Factor (VEGF)

作者：Deuschle M^*; Gilles M; Scharnholz B; Kahl K G

来源：Pharmacopsychiatry, 2015, 48(7): 292-293.

DOI：10.1055/s-0035-1555849

• vascular endothelial growth factor (VEGF)
• brain-derived neurotrophic factor (BDNF)
• depression
• remission
• antidepressant

Introduction: Depression, stress and antidepressant treatment have been found to modulate the expression of growth factors.
Methods: We studied depressed patients receiving randomized treatment with venlafaxine or mirtazapine for 28 days.
Results: There was no significant difference between baseline VEGF concentrations in depressed patients compared to healthy controls. We found no significant effect of antidepressant treatment on serum VEGF.
Discussion: In contrast to serum BDNF, VEGF may not be a suitable biomarker for effects of antidepressant treatment with venlafaxine or mirtazapine.

• 出版日期2015-11
• 单位上海市精神卫生中心