Anticonvulsant activity of furanocoumarins and the essential oil obtained from the fruits of Heracleum crenatifolium

作者：Tosun Fatma^*; Kizilay Cigdem Akyuez; Erol Kevser; Kilic Fatma Sultan; Kuerkcueoglu Mine; Baser Kemal Huesnue Can

来源：Food Chemistry, 2008, 107(3): 990-993.

DOI：10.1016/j.foodchem.2007.08.085

• Heracleum crenatifolium
• furanocoumarin
• essential oil
• anticonvulsant
• MES

The anticonvulsant activity of furanocoumarins, coumarin mixture and the essential oil obtained from the fruits of Heracleum crenatifolium was examined against maximal electroshock (MES)-induced seizures in mice. Bergapten showed significant anticonvulsant activity. The furanocoumarins isolated from the fruits of the plant were identified using thin-layer chromatography, melting points and spectroscopic methods (IR, MS, H-1 NMR) as isobergapten (1), pimpinellin (2), bergapten (3), isopimpinellin (4), sphondin (5) and byak-angelicol (6). The essential oil content of the fruits were found as 5.5%. Twenty-two compounds representing 99.3% of the essential oil obtained from the fruits of H. crenatifolium were determined and the major components were identified as octanol and octyl acetate (3.1% and 88.4% respectively) by GC and GC-MS.

• 出版日期2008-4-1