Adipokine Profile and Urinary Albumin Excretion in Isolated Growth Hormone Deficiency

作者：Oliveira Carla R P; Salvatori Roberto^*; Meneguz Moreno Rafael A; Aguiar Oliveira Manuel H; Pereira Rossana M C; Valenca Eugenia H A; Araujo Vanessa P; Farias Natalia T; Silveira Debora C R; Vieira Jose G H; Barreto Filho Jose A S

来源：Journal of Clinical Endocrinology & Metabolism, 2010, 95(2): 693-698.

DOI：10.1210/jc.2009-1919

Background: GH deficiency (GHD) is often associated with cardiovascular risk factors, including abdominal fat accumulation, hypercholesterolemia, and increased C-reactive protein. Despite the presence of these risk factors, adults with congenital lifetime isolated GHD (IGHD) due to an inactivating mutation in the GHRH receptor gene do not have premature atherosclerosis.
Objective: The aim was to study the serum levels of adiponectin and leptin (antiatherogenic and atherogenic adipokine, respectively), and the urinary albumin excretion (UAE) in these IGHD individuals.
Design and Patients: We conducted a cross-sectional study of 20 IGHD individuals (seven males; age, 50.8 +/- 14.6 yr) and 22 control subjects (eight males; age, 49.9 +/- 11.5 yr).
Main Outcome Measures: Anthropometric factors, body composition, blood pressure, serum adiponectin, leptin, and UAE were measured.
Results: Adiponectin was higher [12.8 (7.1) vs. 9.7 (5) ng/ml; P = 0.041] in IGHD subjects, whereas no difference was observed in leptin [7.3 (6.3) vs. 9.3 (18.7 ng/ml] and UAE [8.6 (13.8) vs. 8.5 (11.1) mu g/min].
Conclusions: Subjects with lifetime untreated IGHD have an adipokine profile with high adiponectin and normal leptin levels that may delay vascular damage and lesions of the renal endothelium. (J Clin Endocrinol Metab 95: 693-698, 2010)

• 出版日期2010-2