Association of E-cadherin (CDH1) gene polymorphisms and gastric cancer risk

作者：Al Moundhri Mansour S^*; Al Khanbashi M****; Al Kindi Mohammed; Al Nabhani Maryam; Burney Ikram A; Al Farsi Abdulaziz; Al Bahrani Bassim

来源：World Journal of Gastroenterology, 2010, 16(27): 3432-3436.

DOI：10.3748/wjg.v16.i27.3432

• Gastric cancer
• Polymorphism
• CDH1

AIM: To investigate the associations between CDH1 gene polymorphisms and gastric cancer (GC) risk predisposition.
METHODS: We analyzed four CDH1 polymorphisms (+54 T>C, -160 C>A, -616 G>C, -3159 T>C) in an Omani population, by extraction of genomic DNA from the peripheral blood of 192 patients with GC and 170 control participants and performed CDH1 genotping using DNA sequencing.
RESULTS: CDH1 -160 -AA genotype was associated with an increased risk of GC (OR = 3.6, 95% CI: 1.1-11.8) (P = 0.03). There was no significant association between the other polymorphisms and GC risk. The haplotpe analysis of +54 T>C, -160 C>A, -616 G>C, -3159 T>C genotypes revealed that the OR of CCGC and CAGC haplotypes was 1.5 (95% CI: 0.7-3.5) and 1.5 (95% 0: 0.2-3.0), but did not reach statistical significance.
CONCLUSION: The current study suggests that the -160 AA genotype was associated with an increased risk of GC in Oman.

• 出版日期2010-7-21