Molecularly-imprinted Calcium Phosphate/Calcium Alginate Composite Microspheres by Surface Imprinting via Silane Crosslinking

作者：Zhao Kongyin; Gao Ning; Liu Chao; Cheng Guoxiang^*

来源：Adsorption Science and Technology, 2008, 26(8): 631-641.

This paper describes the development of a new type of molecularly-imprinted composite microspheres. Composite microspheres of calcium phosphate/calcium alginate (CP/CA CMs) were prepared from calcium phosphate and sodium alginate through the use of calcium chloride (CaCl(2)) as a gelling agent in an inverse suspension. Molecularly-imprinted calcium phosphate/calcium alginate composite microspheres (CP/CA MICMs) were then prepared by surface imprinting using CP/CA CMs Lis the supporting matrix, ethylene tri(beta-methoxy)ethoxysilane (A-172) and gamma-amidopropyltriethoxysilane (KH-550) as the functional monomers and crosslinking agents, respectively, and Methyl Orange as the template in aqueous solution.
The CP/CA MICMs and non-imprinted composite microspheres (NICMs) were characterized by Fourier-transform infrared spectroscopy and optical microscopy. The adsorption behaviour of the CP/CA MICMs and NICMs were determined by ultraviolet spectrophotometry. The results indicated that molecular imprinting occurs via the crosslinking of silanes on the surface of the CP/CA CMs, and that CP/CA MICMs possess an adsorption capacity which exhibits greater selectivity. A schematic representation of the imprinting and recognition process of CA/CP MICMs by Surface imprinting via silane crosslinking was presented.

• 出版日期2008
• 单位天津工业大学; 天津大学