Anti-inflammatory Endiandric Acid Analogues from the Roots of Beilschmiedia tsangii

作者：Huang Yun Ting; Chang Hsun Shuo; Wang Guei Jane; Cheng Ming Jen; Chen Chu Huang; Yang Yi Jen; Chen Ih Sheng^*

来源：Journal of Natural Products, 2011, 74(9): 1875-1880.

DOI：10.1021/np200279r

Bioassay-guided fractionation of roots of Beilschmiedia tsangii led to the isolation of six new endiandric acid analogues: tsangibeilin A (1), tsangibeilin B (2), endiandramide A (3), endiandric acid K (4), endiandric acid L (5), and endiandramide B (6). Also isolated were two new lignans, beilschminol A (7) and tsangin C (8), and six known compounds. The structures of 1-8 were determined by spectroscopic techniques. Compounds 3 and 6 exhibited potent iNOS inhibitory activity, with IC(50) values of 9.59 and 16.40 mu M, respectively.

• 出版日期2011-9
• 单位中国医科大学