An epigenetic view of developmental diseases: new targets, new therapies

作者：Xie, Pei; Zang, Li-Qun; Li, Xue-Kun; Shu, Qiang^*

来源：World Journal of Pediatrics, 2016, 12(3): 291-297.

DOI：10.1007/s12519-016-0020-3

• congenital heart disease
• development
• DNA modification
• 5-hydroxymethylcytosine
• neurological disorders
• RNA modification

Background: Function of epigenetic modifications is one of the most competitive fields in life science. Over the past several decades, it has been revealed that epigenetic modifications play essential roles in development and diseases including developmental diseases. In the present review, we summarize the recent progress about the function of epigenetic regulation, especially DNA and RNA modifications in developmental diseases. @@@ Original research articles and literature reviews published in PubMed-indexed journals. @@@ DNA modifications including methylation and demethylation can regulate gene expression, and are involved in development and multiple diseases including Rett syndrome, Autism spectrum disorders, congenital heart disease and cancer, etc. RNA methylation and demethylation play important roles in RNA processing, reprogramming, circadian, and neuronal activity, and then modulate development. @@@ DNA and RNA modifications play important roles in development and diseases through regulating gene expression. Epigenetic components could serve as novel targets for the treatment of developmental diseases.

• 出版日期2016-8
• 单位浙江大学