Anticomplementary activity of triterpenoids from the whole plant of Aceriphyllum rossii against the classical pathway

作者：Min Byung Sun^*; Lee Iksoo; Chang Min Jung; Yoo Jae Kuk; Na MinKyun; Hung Tran Manh; Thuong Phuong Thien; Lee JongPill; Kim Jung Hee; Kim Jin Cheol; Woo Mi Hee; Choi Jae Sue; Lee Hyeong Kyu; Bae KiHwan

来源：Planta Medica, 2008, 74(7): 726-729.

DOI：10.1055/s-2008-1074534

• Aceriphyllum rossii
• Saxifragaceae
• anticomplement activity
• classical pathway
• olean-27-carboxylic acid derivatives

To provide a better understanding of the anticomplement activity of triterpenoids, seven unusual pentacyclic triterpenoids bearing a carboxyl group at C-27 were evaluated for their anticomplement activities against the classical pathway of the complement system. The triterpenoids were isolated from the whole plant of Aceriphyllum rossii of the family Saxifragaceae and were determined to be 3 alpha,23-isopropylidene-dioxyolean-12-en-27-oic acid (1),3-oxoolean-12-en-27-oic acid (2), 3 alpha-hydroxyolean-12-en-27-oic acid (3), beta-peltoboykinolic acid (4), 3 alpha,23-diacetoxyolean-12-en-27-oic acid (5), 23-hydroxy-3-oxoolean-12-en-27-oic acid (6) and aceriphyllic acid A (7). Among them, compounds 2, 3, and 5 showed significant anticomplement activity on the classical pathway with IC(50) values of 71.4, 98.5, and 180.7 MM, respectively, whereas compounds 1, 4, 6, and 7 were inactive. Our findings suggest that both the ketone at C-3 and the methyl at C-23 in the oleanane triterpenoids with a carboxyl group at C-27 are important for the anticomplement activity against the classical pathway.

• 出版日期2008-6