Nasal provocation test in house dust mite: Does the tested species make a difference?

作者：Haxel B R^*; Huppertz T

来源：Allergologie, 2017, 40(5): 179-184.

DOI：10.5414/ALX1915

• allergic rhinitis
• skin-PRICK-test
• specific IgE
• Dermatophagoides pteronyssinus
• Dermatophagoides farinae

In general, a cross reactivity between Dermatophagoides pteronyssinus (DP) and Dermatophagoides farinae (DF) is assumed in house dust mite (HDM) allergy. Therefore a nasal provocation testing (NPT) should show similar results in both mite species. The aim of this investigation was to evaluate if this assumption proves to be correct in every day clinical practice. Methods: Data of 70 patients with symptoms of HDM-allergy who underwent NPT, skin testing, and blood tests for specific IgE were analyzed retrospectively. The results of NPT with both mites species were compared. Results: A concordant outcome of the NPT was found in 80% of the patients (45% both negative and 35% both positive). In approximately 10% a positive test was found after provocation with one mite type (DP or DF). The results of skin testing and specific blood-IgE were very variable but showed no differences between the mite species. Conclusions: In patients with clinically diagnosis of HDM-allergy and negative NPT for one HDM-species (DF or DP), the second species should be tested additionally, as in up to one fifth of the patients investigated in this study, NPT was positive for one species only. Neither skin tests nor specific blood IgE were able to predict which HDM-type caused as a positive provocation.

• 出版日期2017-5