Daptomycin for highly resistant Enterococcus faecium infection

作者:Rosin Christiane*; Bernsmeier Christine; Entenza Jose M; Moreillon Philippe; Frei Reno; Weisser Maja; Flueckiger Ursula
来源:Swiss Medical Weekly, 2012, 142: w13603.
DOI:10.4414/smw.2012.13603

摘要

We report a case series of 11 patients with severe E. faecium infections treated with daptomycin. All strains were resistant to ampicillin (MIC %26gt;8 mg/l), but susceptible to vancomycin. Seven out of 11 strains were also highly resistant to gentamicin (MIC %26gt;500 mg/l). All patients were treated with multiple broad-spectrum antibiotics prior to isolation of E. faecium and had severe underlying diseases. Our experience suggests that salvage therapy with daptomycin might be a safe and efficacious treatment for E. faecium infections.

  • 出版日期2012-6-26