A critical analysis of the concept of secondary Oral Hypoglycemic Agent (OHA) failure in type 2 diabetes at a tertiary care hospital

作者：Vidyasagar Sudha; Nataraj; Varma Muralidhar; Prashanth C K; Rao Yeshwanth^*; Kavitha B

来源：International Journal of Diabetes in Developing Countries, 2011, 31(3): 161-165.

DOI：10.1007/s13410-011-0037-z

• OHA failure
• Beta cell dysfunction
• Type 2 diabetes

Data from UKPDS study suggests that the onset of cell dysfunction in diabetes occurs well before the development of hyperglycemia. To study the concept of secondary OHA failure in type 2 diabetes patients of more than 10 years duration in a tertiary care hospital. A retrospective analysis of all the cases of type 2 diabetes mellitus of more than 10 years duration from 2002 to 2003 was done and the data was divided into three groups: oral hypoglycemic agents (OHA) only, Insulin only, OHA + insulin. ANOVA/Students t test was the primary statistical test used. Odds ratio and 95% CI were calculated to compare risks of other diseases and drug use. 62.35% were on only OHAs, 8.82% on only insulin and 28.82% on both insulin and OHAs. This confirms good efficacy of OHAs. Diabetic population in our study tends to have a preserved beta cell function and secondary OHA failure is a late feature.

• 出版日期2011-9