Tollip: a multitasking protein in innate immunity and protein trafficking

作者：Capelluto Daniel G S^*

来源：Microbes and Infection, 2012, 14(2): 140-147.

DOI：10.1016/j.micinf.2011.08.018

• Tollip
• Innate immunity
• Toll-like receptor
• Phosphoinositides
• Ubiquitin

The Toll-interacting protein (Tollip) is a critical regulator of Toll-like receptor (TLR)-mediated innate immune responses. Tollip modulates TLR signaling and membrane trafficking processes through its interaction with both proteins and phosphoinositides. Here, I discuss the multitasking role of Tollip associated with its modular architecture.

• 出版日期2012-2
• 单位美国弗吉尼亚理工大学(Virginia Tech)