An unprecedented case of dodecamorphism: the twelfth polymorph of aripiprazole formed by seeding with its active metabolite

作者：Zeidan T A^*; Trotta J T; Tilak P A; Oliveira M A; Chiarella R A; Foxman B M; Almarsson Oe; Hickey M B

来源：CrystEngComm, 2016, 18(9): 1486-1488.

DOI：10.1039/c5ce02467f

A new polymorph of aripiprazole has been discovered, making it the most polymorphic drug to date with twelve reported anhydrous forms, and a record-breaking ninth solved crystal structure. The new form was induced by seeding with crystals of the active metabolite dehydro-aripiprazole.

• 出版日期2016